TY - JOUR AU - Susianto, Susianto PY - 2020/06/29 Y2 - 2024/03/29 TI - EFEK FORTIFIKASI VITAMIN B12 TERHADAP KADAR VITAMIN B12 SERUM DAN HOMOSISTEIN SERUM PADA VEGETARIAN JF - Jurnal Ilmu Kesehatan Bhakti Husada: Health Sciences Journal JA - J. Ilmu Kesehat. Bhakti Husada Heal. Sci. J. VL - 11 IS - 1 SE - Articles DO - 10.34305/jikbh.v11i1.150 UR - https://ejournal.stikku.ac.id/index.php/stikku/article/view/150 SP - 114-120 AB - <p><strong><em>Introduction</em></strong><em>: </em><em>Vegetarians consume plant-based foods with or without eggs and milk</em>.<em> Vegetarians are at risk of vitamin B<sub>12</sub> deficiency, as natural sources of vitamin B<sub>12</sub> are limited to animal-based foods.</em> <em>Vitamin B<sub>12</sub> deficiency can lead to megaloblastic anemia, nerve damage and increase homocysteine level. Higher homocysteine level can increase the risk of coronary heart disease and stroke. The objective of this study was to investigate the effect of vitamin </em><em>B<sub>12</sub></em> <em>fortification on the level of serum vitamin B<sub>12</sub> and homocysteine in vegetarian. </em><strong><em>Method</em></strong><em>: </em><em>The research design was an experimental study, community trial. The samples were 42 vegetarians with vitamin B<sub>12</sub> deficiency (&lt; 156 pmol/L) selected from 118 vegetarians as members of Indonesia Vegetarian Society (IVS) Pekanbaru, treated by vitamin B<sub>12 </sub>fortified oatmeal for three months from March to June 2010. </em><em><sub>&nbsp;</sub></em><em>S</em><em>erum vitamin B<sub>12</sub> and homocysteine were measured by electrochemiluminescent immunoassay and microparticle enzyme immunoassay method respectively.</em></p><p><strong><em>Result</em></strong><em>: </em><em>Prevalence of vitamin B<sub>12</sub> deficiency in vegetarian was 35.6%.</em> <em>Statistical analysis showed a significant increase of serum vitamin B<sub>12</sub> from 124.6 to 284.6 pmol/L (p=0.001) and significant decrease of serum homocysteine from 20.1 to 15.1 </em><em>µmol/L (p=0.001).</em></p><p><strong><em>Conclusion</em></strong><em>: Consumption of </em><em>vitamin </em><em>B<sub>12</sub></em><em> fortified oatmeal increases the level of serum vitamin </em><em>B<sub>12 </sub></em><em>and decreases the level of serum homocysteine significantly in vegetarian with vitamin </em><em>B<sub>12 </sub></em><em>deficiency. </em></p> ER -